Principal Scientist/Director, Preclinical

Preclinical · Vancouver, British Columbia
Department Preclinical
Employment Type Full-Time

Principal Scientist/Director, Preclinical


Acuitas Therapeutics is a private biotechnology company based in Vancouver, British Columbia, Canada. We are the premier global provider of LNP delivery systems for nucleic acid therapeutics. Acuitas is partnered with multiple international, biotechnology and pharmaceutical partners who are focused on bringing new vaccines and drugs into clinical development and to the marketplace.


At Acuitas Therapeutics (Acuitas) we believe in combining excellent science with an enviable work culture. The advanced LNP technologies we provide for our partners are made possible by our employees who apply their passion, curiosity, and knowledge every step of the way.  At Acuitas you will have the opportunity to work as part of a close-knit team of exceptional scientists, who support the production of revolutionary technology that impacts the health and wellness of society.  By living our values, including honesty, integrity, innovation and openness we have fostered a supportive work environment where our employees feel empowered, challenged, recognized and rewarded. If you would like to work for a company that is at the top of the field Acuitas is the company for you!


 All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, status as a protected veteran, or any other status protected by applicable law.


 Role Summary:


The Principal Scientist/Director, Preclinical will be responsible for preclinical operations and will contribute to overall strategic scientific planning.  She/he will work closely with the Senior Director, Preclinical and the Chief Scientific Officer.  


Duties and Responsibilities:


Responsibilities will include oversight of preclinical activities for both internal and partnered programs.  A significant proportion of the preclinical studies will be performed externally and will involve coordination, management and oversight of all aspects of studies being executed at domestic and foreign external contract research organizations.  These studies will support both Acuitas’ internal and partnered research programs. Acuitas is partnered with multiple international biotechnology and pharmaceutical companies and the successful candidate will interact directly with partners on multiple programs.   He/she will participate in a number of cross-functional teams.


Expertise and accountabilities will include:


  • Strong experience with planning, execution and writing/reviewing nonclinical portions of regulatory submissions and nonclinical studies management through the various product and clinical development stages
  • CRO management
  • Translational sciences (bridging understanding between nonclinical and clinical studies)
  • Mechanistic studies (pharmacology/toxicology)
  • Experience with nucleic acid and/or nanoparticle development programs would be an asset
  • Experience with ADME studies would be an asset


The successful candidate will have a PhD, MSc or equivalent degree and a minimum 10 years industry experience in a biotechnology/pharmaceutical environment. The successful candidate will be a strategic thinker and problem-solver and have excellent verbal and written communication skills. She/he will excel in a fast-paced, growing environment and will enjoy working as part of a team. She/he will exhibit strong leadership skills and be an excellent mentor. She/he will share the company’s values of honesty, integrity, innovation and openness. Compensation will be commensurate with the successful candidate’s experience and qualifications.



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  • Location
    Vancouver, British Columbia
  • Department
  • Employment Type