Research Associate / Scientist – Synthetic Chemistry

Chemistry · Vancouver, British Columbia
Department Chemistry
Employment Type Full-Time
Minimum Experience Mid-level

YOU: A committed professional with experience in synthetic organic and/or medicinal chemistry looking to develop further in an innovative, fast paced biotech environment.

 

US: Leading innovators in the lipid nanoparticle (LNP) field, looking for a talented individual to join our collaborative, passionate, diverse pharmaceutical focused team.

 

ROLE SUMMARY:

 

Acuitas Therapeutics is seeking a highly skilled MSc or PhD level scientist with expertise in synthetic organic and/or medicinal chemistry to work in the Chemistry Group, reporting to the Director, Chemistry. The role holder will be responsible for the design, synthesis and characterization of novel compounds in support of our ongoing development of state-of-the-art LNP formulations for nucleic acid delivery.  They will work as part of a cross-functional team, regularly interacting with our analytical chemistry, formulations and preclinical research groups.

 

JOB DESCRIPTION:


The Research Associate/Scientist will work at the bench performing research related to the design, synthesis and characterization of novel lipids for use in LNP formulations.  They will contribute to the understanding of the structure activity relationship (SAR) of these compounds and suggest further iterative improvements to the compounds to provide optimal performance of our LNP formulations.


Working with the Director, Chemistry, the responsibilities would include:

 

  1. Synthesis, purification and characterization of a variety of lipids and small molecules.
  2. Contribute to the design of new compounds based on current understanding of the SAR and feedback from colleagues in other disciplines across the organization.
  3. Work effectively in a cross-functional team and contribute to team, departmental and organizational meetings.
  4. Assist in technology transfer related to the scale up of compounds discovered in our labs.
  5. Keep detailed lab notes at industry standards.
  6. Participate in drafting the technical portion of intellectual property filings and research papers.
  7. Lab management duties as required.
  8. Collaborative analytics with other departments including Formulation Development, Process Development and Pre-Clinical.
  9. Maintain familiarity with relevant scientific knowledge and advancements.

 

QUALIFICATIONS AND SKILLS:

 

  • MSc with 8+ years’ experience or a PhD with 5+ years’ experience in a drug discovery/synthetic chemistry/medicinal chemistry organization.
  • Current and comprehensive knowledge of modern synthetic organic chemistry, purification and characterization techniques.
  • Experience in optimizing discovery scale chemical reactions to enable multi-gram synthesis is an asset.
  • The ability to develop and master new techniques quickly and to be able to work independently.
  • Familiarity with industry standard chemistry-specific software and cheminformatics tools.

 


ABOUT ACUITAS THERAPEUTICS


Acuitas Therapeutics is a private biotechnology company based in Vancouver, British Columbia, Canada. We are the premier global provider of LNP delivery systems for nucleic acid therapeutics. Acuitas is partnered with multiple international, biotechnology and pharmaceutical partners who are focused on bringing new vaccines and drugs into clinical development and to the marketplace. As an organization, we focus on fostering an inclusive and supportive work environment reflecting our values of honesty, integrity, innovation and openness. We strive to work internally and with our partners in an ethical, collegiate and respectful manner.

Thank You

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  • Location
    Vancouver, British Columbia
  • Department
    Chemistry
  • Employment Type
    Full-Time
  • Minimum Experience
    Mid-level